Mucosa-associated Lymphoid Tissue (MALT) Lymphoma of the Lung Treated by Surgery and Rituximab;Report of a Case

Feb 2013

[Article in Japanese]

Yoshida C, Tarumi S, Kato A, Nii K, Chang SS, Yokomise H.

Source

Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Abstract

We report a case of mucosa-associated lymphoid tissue (MALT) lymphoma of the lung treated by surgery and rituximab. A 47-year-old man was referred to our hospital because of the lesion in the right middle lobe, which had enlarged gradually. Chest computed tomography(CT) scanning showed an infiltrative shadow of the right middle lobe. He underwent right middle lobectomy for the MALT lymphoma whose diagnosis and treatment. The tumor was pathologically diagnosed as CD20 immunostaining was positive and the adjuvant treatment by rituximab was performed.

PierOnline

Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum.

Jul 2012

De Sanctis V, Marignani M, Angeletti S, Assisi D, Armosini V, Valeriani M, Minniti G, Cox MC, Ruco L, Enrici RM.

Abstract 

Primary rectal MALT lymphoma is a very rare entity among extranodal MALT lymphomas and its therapeutic management has not been standardized. Different approaches including surgery, chemotherapy and radiotherapy have been proposed in the last decades. There have been reports on complete responses after anti-Helicobacter pylori therapy, also in patients without serological or histological evidence of Helicobacter pylori infection. In our patient we obtained a complete response with anti-Helicobacter pylori therapy and a disease-free survival of 34 months. Endoscopic ultrasound was useful for diagnosis and follow-up. Although the mechanisms that determined this response remain a matter of debate, anti-Helicobacter pylori therapy can be considered as first-line therapy in stage IE, nonbulky primary rectal MALT lymphoma. Endoscopic ultrasound could play a relevant role in the management of this rare condition

Journal of Experimental and Clinical Oncology

Clinical manifestations of primary pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Japanese population.

Jan 2012

Ogusa E, Tomita N, Ishii Y, Takasaki H, Hattori Y, Matsumoto C, Ishigatsubo Y.

Source

Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan.

Abstract

We retrospectively analysed 16 cases of newly diagnosed pulmonary mucosa-associated lymphoid tissue (MALT)lymphoma in the Japanese population. The disease was found on the basis of examination findings in 14 cases, and clinical manifestations in 2. According to the extensive staging procedure, four patients had concomitant gastric involvement. Primary treatment involved surgery alone in two patients; surgery followed by rituximab (R)-containing chemotherapy in two; R-containing chemotherapy alone in 11; and chemoradiotherapy without R in one. Over the median observation period of 28 months, disease progression was recorded in three patients, but all 16 patients were alive at the end of the observation period. One patient was treated with R alone and achieved partial remission; subsequent tentative surgery showed no evidence of residual lymphoma. It has been 72 months of progression-free survival after the diagnosis. Primary pulmonaryMALT lymphoma exhibited an indolent clinical course. R has potential as a therapeutic agent in patients with pulmonaryMALT lymphoma.

Keywords:

• MALT lymphoma;
• lung;
• rituximab

Wiley Online

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What is gastric MALT lymphoma?

What is gastric MALT lymphoma?
Gastric MALT lymphoma is a type of Non Hodgkin Lymphoma (NHL) affecting the stomach

Treatment options for gastric MALT lymphoma:

The following treatments can be used for gastric MALT lymphomas:
Treatment of Helicobacter pylori infection
Radiation therapy
Surgery
Chemotherapy

Let us look at how these different treatments fit in.

Treatment of H pylori infection:

Many cases of MALT lymphoma of the stomach are strongly associated with infection with H pylori, a bacterium that commonly causes gastritis and stomach ulcers. It has been seen that in those patients with MALT lymphoma who also test positive for H pylori, antibiotics for H pylori may actually control the cancer. In 3 out of 4 patients with early disease, H pylori treatment may result in a complete resolution of the tumor. The disease remains controlled in many patients. Those with complete response may be kept on regular follow-up with endoscopies. Cancer treatment may be kept in reserve for later.

Radiotherapy for MALT lymphoma:

Radiation is the preferred treatment for MALT lymphoma when H pylori is absent, or when anti H pylori treatment fails. Relatively low doses of radiation are given, and these doses nearly always control the lymphoma. Radiotherapy treatment alone can cause complete response in more than 95% of the patients, and most patients remain controlled in the long term.

Surgery for MALT lymphoma of the stomach:

Surgery is an effective treatment of MALT lymphomas of the stomach and results in long term control in most patients. The potential morbidities of surgery are higher than those of radiation, and therefore surgery is less commonly used for treatment. Like radiotherapy, surgery is usually sufficient to control and cure MALT lymphomas that are limited to the stomach.

Chemotherapy for MALT lymphoma:

Chemotherapy is generally used for early stage gstric MALT lymphomas when local teatments fail to control disease or when the disease recurs. For advanced stage lesions chemotherapy is the treatment of choice. Different combination treatments are effective in these slow growing lymphomas.

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